Fataki, Maulidi R.Ndossi, Godwin D.2022-08-242022-08-241998Fawzi, W.W., Mbise, R.L., Fataki, M.R., Herrera, M.G., Kawau, F., Hertzmark, E., Spiegelman, D. and Ndossi, G., 1998. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. The American journal of clinical nutrition, 68(1), pp.187-192.https://doi.org/10.1093/ajcn/68.1.187http://hdl.handle.net/123456789/1031Vitamin A deficiency and acute lower respira- tory tract infections coexist as important public health problems in many developing countries. We carried out a randomized, double-blind, placebo-controlled trial to examine whether large doses of vitamin A given to Tanzanian children who are admit- ted to the hospital with nonmeasles pneumonia would reduce the severity of respiratory disease. Six hundred eighty-seven chil- dren were randomly assigned to receive either placebo or vita- min A [200 000 IU (60 mg retinol equivalents) for children > 1 y of age and 100 000 IU (30 mg retinol equivalents) for infants] on the day of admission and another dose on the following day. Of the 346 children in the vitamin A group, 13 died in the hospital, compared with 8 of 341 children in the placebo group; the rela- tive mortality was 1.63 (95% CI: 0.67, 3.97; P = 0.28). The mean number of days of hospitalization was the same in both groups (4.2 d). There were no differences between the vitamin A and placebo groups in the duration of hospital stay when examined within categories of children stratified by age, sex, breast-feed- ing status, nutritional status at baseline, or quartile of dietary vit- amin A intake in the 4 mo before admission to the hospital. There were also no differences in the mean number of days of fever, rapid respiratory rate, or hypoxia, whether these endpoints were examined in the total number of subjects or in a subset with more severe clinical conditions at baseline. Large doses of vita- min A had no protective effect on the course of pneumonia in hospitalized Tanzanian children.enVitamin ASupplementsTanzaniaArticle