Mgonda, Yassin M.2020-10-262020-10-261998Mgonda, Y.M., Ramaiya, K.L., Swai, A.B., McLarty, D.G. and Alberti, K.G.M., 1998. Insulin resistance and hypertension in non-obese Africans in Tanzania. Hypertension, 31(1), pp.114-118.https://doi.org/10.1161/01.HYP.31.1.114http://hdl.handle.net/123456789/713Abstract—Insulin sensitivity was assessed using a glucose-insulin infusion test in 15 newly diagnosed non-obese hypertensive black Tanzanians with normal glucose tolerance and in 15 normotensive control subjects matched for age, sex, and body mass index. The steady-state blood glucose and metabolic clearance rate of glucose (MCR) were used as measures of insulin sensitivity. The mean MCR (glucose) was significantly reduced (7.12±0.57 versus 9.50±0.69 μmol/kg per minute; P<.05) and mean steady-state blood glucose was significantly elevated (5.0±0.3 versus 3.7±0.3 mmol/L; P<.01) in subjects with hypertension compared with the normotensive group. For all subjects there was a significant inverse correlation between MCR (glucose) and systolic (P=.003) and diastolic (P=.005) blood pressure; and a positive correlation was found between fasting serum insulin levels and systolic (P=.005) and diastolic (P=.004) blood pressure. These observations were independent of body mass index and serum lipid levels. These data indicate a strong association between insulin mediated glucose uptake and blood pressure in this population of normal weight untreated urban Africans.enBlood pressureAfricansInsulin resistanceArticle