Moshi, Mainen J.2023-08-112023-08-112000-01-10Moshi, M.J. and Nagpa, V., 2000. Effect of Caesalpina Bonducella Seeds on Blood Glucose in Rabbits. Pharmaceutical biology, 38(2), pp.81-86.https://doi.org/10.1076/1388-0209(200004)3821-1FT081http://hdl.handle.net/123456789/1091The seeds of Caesalpinia bonducella (L.) Flem. (Cae-salpiniaceae) are sold in shops in Dar es Salaam,Tanzania, for the treatment of diabetes mellitus. A sus-pension of the powdered seed kernel in 0.5% car-boxymethylcellulose (CMC) was tested for ability tolower blood glucose in fasted and glucose-fed normalalbino rabbits. Following administration of 0.2, 0.4 and 0.8 g/kg body weight of the powder there was nodifference in areas under the fasting blood glucose andoral glucose tolerance test (OGTT) curves as com-pared to controls given CMC (P 0.05). Similarly, 0.2g/kg body weight of the powder administered for 7consecutive days had no effect on either fasting bloodglucose or the clearance of a glucose load from the blood. However, 0.1 g/kg body weight chlorpropamidesignificantly decreased the area under the fasting blood glucose and OGTT curves as compared to con-trols given CMC (P 0.05). Thus, contrary to a pre-vious report, we could not detect any hypoglycaemic activity in the seeds of Caesalpinia bonducella grow-ing in Dar es SalaamenCaesalpinia bonducellaCaesalpiniaceaeRabbitsArticle