Mashalla, Yohana J.2021-10-282021-10-281991-12-12MASHALLA, Y.J., TOKUI, N. and KIDO, M., 1991. Single Breath Assessment of Bronchial Responsiveness: A Comparison with the Astograph Method. Journal of UOEH, 13(1), pp.1-11.https://www.jstage.jst.go.jp/article/juoeh/13/1/13_KJ00002572295/_pdf/-char/jahttp://hdl.handle.net/123456789/850Bronchial responsiveness to inhaled doubling concentrations of acetylcholine using the astograph and single breathtechniques was assessed im 7 males and 11 females <meanage 22.7, SD==2,05 and 21.2, SD== 1.11},ears tbr male and femule respectivcly) healthy volunteers. Eleven (61%> of the subjects had neither a historyof allcrgy nor whcczcs. Five<28%)haclallcrgic rhinitis and two (11%)had asthma. Seven (64%)ef the normal subjects, all asthmatic and sulijects with allergic rhinitis responded to inhaled acetylcholine. Respiratery conductance (Grs}and the one second ft)rsedexpired volume (FEVD expressed as percentages of thc baselinevalues were compared on a semilogarithmic scalc against cumulativc dosc. In most sub.iccts thc pattern of the curves showed c]ose similarities in the two methods. 'I'hebronchial sensitivity i.e.minimum cumulativc dosc of acctylcholinc justsuMcient to start a fallin the FEVL and Grs(C.i,,s and C.,t.Arespectively), showcd good corrclation (r=O,750,P<O,Ol), Thc rcsults indicatethat bronchial responsiveness can be reliably assessed using the simple single breath methed as well as the more complex astograph mcthod.enRespiratory conductanceAstographBronchial sensitivityArticle